Synergy between Acute Intermittent Hypoxia and Task-Specific Training
Joseph F. Welch, Tommy W. Sutor, Alicia K. Vose, Raphael R. Perim, Emily J. Fox, Gordon S. Mitchell
Abstract
Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working model of neural network and cellular elements to explain AIH-TST synergy. Our goal is to forecast experiments necessary to advance our understanding and optimize the neurotherapeutic potential of AIH-TST.
Topics & Concepts
Hypoxia (environmental)Intermittent hypoxiaNeuroscienceTask (project management)Spinal cord injuryPhysical medicine and rehabilitationMedicineSpinal cordPsychologyAnesthesiaChemistryOxygenOrganic chemistryObstructive sleep apneaManagementEconomicsNeuroscience of respiration and sleepSpinal Cord Injury ResearchHigh Altitude and Hypoxia