Visible <scp>Light‐Induced Copper‐Catalyzed</scp> C—H Arylation of Benzoxazoles<sup>†</sup>
Xiaodong Ma, Guozhu Zhang
Abstract
Summary of main observation and conclusion A general method for visible light‐induced copper‐catalyzed arylation of sp 2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzooxazole and benzothiazole can be arylated. Furthermore, electron‐poor heterocycles such as thiophene possessing one electron‐withdrawing group can also be arylated.
Topics & Concepts
ChemistryBenzothiazoleArylCopperHalideThiopheneAlkoxideLithium (medication)CatalysisVisible spectrumCoupling (piping)Combinatorial chemistryMedicinal chemistryPhotochemistryOrganic chemistryAlkylOptoelectronicsEngineeringEndocrinologyMechanical engineeringMedicinePhysicsCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques