IDENTIFICATION OF SECONDARY METABOLITES AND ANTIDIARRHEAL ACTIVITY OF PIRDOT LEAVES ETHANOL EXTRACT (Saurauia vulcani Korth.) FROM WEST PAKPAK, NORTH SUMATERA PROVINCE, INDONESIA
Kasta Gurning, Rain Kihara Boangmanalu, Herryanto Agustriadi Simanjuntak, N. Singarimbun, R. Rahmiati, Widya Lestari
Abstract
Pirdot (Saurauia vulcani Korth) is used by the people of West Pakpak in North Sumatera as medicinal ingredients. This study aims to identify secondary metabolite and to know the antidiarrheal activity of ethanol extract of pirdot leaves which tested on mice male which is induced by oleum rincini. The dosage variation of ethanol extract is 50 mg/kg body weight, 100 mg/kg body weight, and 200 mg/kg body weight. Loperamide was used as a positive control with 2 mg/kg body weight dose, and 0.5% CMC Na as a negative control. Determination of antidiarrheal activity from the frequency of diarrhea, duration of diarrhea, and the consistency of the mice's feces which induced with oleum ricini by comparing the % inhibition from parameters. The results obtained showed that the extract dose 100 mg/kg body weight better than other variation of dose but not better than loperamide 2 mg/kg body weight as an antidiarrheal activity. Based on this research that the extract of pirdot leaves can be used as antidiarrheal with the right dose.