Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
Xinran Wang, Lu Lu, Xiaochuan Hong, Lingling Wu, Chao Yang, You Wang, Wenwen Li, Yuanqin Yang, Dongqing Cao, Wen Di, Liufu Deng
Abstract
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Topics & Concepts
EffectorIntracellularCD8Programmed cell deathImmunotherapyCellT cellCell biologyCytotoxic T cellAdoptive cell transferPD-L1Cancer researchCell therapyChemistryBiologyImmunologyImmune systemApoptosisBiochemistryIn vitroCAR-T cell therapy researchCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses