Baroreflex function in Parkinson's disease: insights from the modified-Oxford technique
Jeann L. Sabino‐Carvalho, Roberta A. Cartafina, Gabriel Magalhães Nunes Guimarães, Pedro Renato de Paula Brandão, J. Lang, Lauro C. Vianna
Abstract
Attenuated baroreflex gain may contribute to adverse cardiovascular outcomes, including orthostatic intolerance symptoms typically observed in patients with Parkinson's disease. We found that the baroreflex gain (assessed by the modified-Oxford technique) is attenuated and accompanied by an increased operating range in patients with Parkinson's disease. These findings highlight that cardiovascular perturbations are required to detect baroreflex impairments and that spontaneous indices do not reveal cardiovagal-baroreflex dysfunction in a middle-aged group of patients with Parkinson's disease.
Topics & Concepts
BaroreflexOrthostatic intoleranceOrthostatic vital signsParkinson's diseaseMedicineDiseaseAutonomic functionCardiologyInternal medicineNeurosciencePsychologyHeart rateBlood pressureHeart rate variabilityHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic DisordersEEG and Brain-Computer Interfaces