Nickel-Catalyzed Chemo- and Regioselective Benzylarylation of Unactivated Alkenes with <i>o</i>-Bromobenzyl Chlorides
Hailong Wang, Haichao Huang, Chao Gong, Yong Diao, Jianmei Chen, Si‐Hai Wu, Lianhui Wang
Abstract
Chemo- and regioselectively nickel-catalyzed reductive benzylarylation of unactivated alkenes with o-bromobenzyl chlorides is disclosed herein, in which electrophiles participate through a single-component double-site approach. Moreover, its utility is underscored by the concise synthesis of bioactive Indane compounds and postreaction functionalizations leading to structurally diverse scaffolds. Preliminary mechanistic investigations suggest a radical chain reaction mechanism.
Topics & Concepts
ChemistryIndaneRegioselectivityCatalysisElectrophileCombinatorial chemistryNickelReductive eliminationComponent (thermodynamics)Organic chemistryThermodynamicsPhysicsCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques