Deciphering the mechanism and binding interactions of Pemetrexed with dsDNA with DNA-targeted chemotherapeutics via spectroscopic, analytical, and simulation studies
Pelin Şenel, Soykan Ağar, Yusuf Serhat İş, Filiz Altay, Ayşegül Gölcü, Mine Yurtsever
Topics & Concepts
ChemistryGuaninePemetrexedHydrogen bondDocking (animal)DNAMolecular dynamicsStereochemistryCombinatorial chemistryBiophysicsNucleotideCisplatinComputational chemistryBiochemistryMoleculeChemotherapyGeneOrganic chemistryBiologyNursingSurgeryMedicineCancer therapeutics and mechanismsDNA and Nucleic Acid ChemistryMetal complexes synthesis and properties