Intragenic DNA methylation regulates insect gene expression and reproduction through the MBD/Tip60 complex
Guanfeng Xu, Hao Lyu, Yangqin Yi, Yuling Peng, Qili Feng, Qisheng Song, Chengcheng Gong, Xuezhen Peng, Subba Reddy Palli, Sichun Zheng
Abstract
ovary, with MBD2/3 knockdown resulting in decreased fecundity. These data uncover a mechanism of gene body methylation for regulating insect gene expression and reproduction.
Topics & Concepts
DNA methylationEpigenetics of physical exerciseBiologyMethylationEpigeneticsRNA-Directed DNA MethylationGeneGeneticsRegulation of gene expressionHistoneHistone methylationEpigenomicsGene expressionMolecular biologyCpG sitePromoterEpigenetics and DNA MethylationCancer-related gene regulationGenomics and Chromatin Dynamics