Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
Sam Kant, Daniel C. Brennan
Abstract
The routine surveillance of kidney transplant allografts has relied on imperfect non-invasive biomarkers such as creatinine and urinary indices, while the gold standard allograft biopsy is associated with risk of bleeding, organ injury and sampling errors. Donor derived cell free DNA (dd-cfDNA) is being employed as a biomarker that addresses limitations of these surveillance methods, albeit has inherent drawbacks. This review provides an update on the enhanced understanding of dd-cfDNA and its expanded use beyond the conventional indication of detecting allograft rejection.
Topics & Concepts
MedicineCell-free fetal DNAKidney transplantationUrinary systemTransplantationBiomarkerGold standard (test)BiopsySampling (signal processing)NephrologyKidneyCreatinineUrologyOncologyInternal medicineIntensive care medicinePregnancyFetusChemistryBiochemistryBiologyComputer scienceComputer visionGeneticsPrenatal diagnosisFilter (signal processing)Renal Transplantation Outcomes and TreatmentsOrgan Transplantation Techniques and OutcomesOrgan Donation and Transplantation