Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes
Seung Eun Lee, Kitae Kwon, Sae Woong Oh, Se Jin Park, Eunbi Yu, Hyeyoun Kim, Seyoung Yang, Jung Yoen Park, Woo‐Jae Chung, Jae Youl Cho, Jongsung Lee
Abstract
attenuated the resorcinol effects on ARE signaling, but knockdown of AhR did not affect resorcinol activation of Nrf2. This suggests that activation of antioxidant activity by resorcinol is not mediated by AhR. These results indicate that resorcinol is protective against effects of B[a]P exposure. The mechanism of action of resorcinol is inhibition of AhR and activation of Nrf2-mediated antioxidant signaling. Our findings suggest that resorcinol may have potential as a protective agent against B[a]P-containing pollutants.
Topics & Concepts
ResorcinolAryl hydrocarbon receptorChemistryGene knockdownHaCaTFluorantheneKeratinocyteBenzo(a)pyreneBiochemistryMolecular biologyCarcinogenPharmacologyBiologyApoptosisTranscription factorIn vitroPyreneGeneOrganic chemistryGenomics, phytochemicals, and oxidative stressCarcinogens and Genotoxicity AssessmentToxic Organic Pollutants Impact