The role of TGF-β in the tumor microenvironment of pancreatic cancer
Qiang Luo, Ziquan Hu, Hongcheng Zhao, Yanmei Fan, Xiancong Tu, Yueqing Wang, Xiaowen Liu
Abstract
Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-β in the tumor microenvironment of PC, highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC.
Topics & Concepts
Tumor microenvironmentPancreatic cancerTransforming growth factorCancer researchCytokineCancerPancreatic tumorMedicineTransforming growth factor betaBiologyInternal medicinePancreatic and Hepatic Oncology ResearchTGF-β signaling in diseasesCancer Cells and Metastasis