Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation
Mengqi Wang, Luyao Li, Shuping Yang, Fangyuan Guo, Gongming Zhu, Bo Zhu, Junbiao Chang
Topics & Concepts
ChemistryApoptosisReactive oxygen speciesOxidative stressIsoxazoleCytotoxicityIntrinsic apoptosisBiochemistryIn vitroProgrammed cell deathStereochemistryCaspaseSynthesis and biological activityRedox biology and oxidative stressSynthesis and Biological Evaluation