Litcius/Paper detail

Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation

Mengqi Wang, Luyao Li, Shuping Yang, Fangyuan Guo, Gongming Zhu, Bo Zhu, Junbiao Chang

2023Bioorganic Chemistry16 citationsDOI

Topics & Concepts

ChemistryApoptosisReactive oxygen speciesOxidative stressIsoxazoleCytotoxicityIntrinsic apoptosisBiochemistryIn vitroProgrammed cell deathStereochemistryCaspaseSynthesis and biological activityRedox biology and oxidative stressSynthesis and Biological Evaluation