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Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors

Mamdouh F. A. Mohamed, Adel A. Marzouk, Ayman Nafady, Dalia A. Elgamal, Rasha M. Allam, Gamal El‐Din A. Abuo‐Rahma, Hussein I. El‐Subbagh, Amr H. Moustafa

2020Bioorganic Chemistry53 citationsDOI

Topics & Concepts

ChemistryCelecoxibCarrageenanAnti-inflammatoryPharmacologyIn vivoLipinski's rule of fiveIC50ArylIn vitroDocking (animal)BiochemistryMedicineOrganic chemistryBiologyGeneNursingIn silicoBiotechnologyAlkylSynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Biological Evaluation
Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors | Litcius