Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types
Chandani Limbad, Ryosuke Doi, Julia McGirr, Serban Ciotlos, Kevin Perez, Zachary S. Clayton, Radha Daya, Douglas R. Seals, Judith Campisi, Simon Melov
Abstract
in mouse skeletal muscle. Thus, 25HC represents a potential class of senolytics, which may be useful in combating diseases or physiologies in which cellular senescence is a key driver.
Topics & Concepts
SenescenceIn vivoCell biologyBiologyCellEndogenyCell typeMetaboliteCell cultureGeneComputational biologyBiochemistryGeneticsTelomeres, Telomerase, and SenescenceAdipose Tissue and MetabolismCircadian rhythm and melatonin