Rapid development of vasopressin resistance in dietary K<sup>+</sup> deficiency
Lama Al‐Qusairi, P. Richard Grimm, Ava M. Zapf, Paul A. Welling
Abstract
This study shows that aquaporin-2 regulation is disrupted by a small fall in plasma potassium levels and the response is influenced by sexual dimorphism in renal potassium handling. The findings provided new insights into the mechanisms by which water balance is altered in dietary potassium deficiency and support defining the disorder as "potassium-dependent nephrogenic diabetes insipidus."
Topics & Concepts
Nephrogenic diabetes insipidusPotassiumPotassium deficiencyEndocrinologyInternal medicineAquaporin 2Diabetes insipidusVasopressinInsulin resistanceSexual dimorphismChemistryMedicineBiologyDiabetes mellitusWater channelOrganic chemistryInletEngineeringMechanical engineeringIon Transport and Channel RegulationElectrolyte and hormonal disordersIon channel regulation and function