Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation
Liping Huang, Jianhua Zhang, Junfei Hu, Tianbao Zhao, Zhipeng Gu
Abstract
fate of the bone biomaterials. Herein, we proposed a biomimetic gelatin methacrylate/nano fish bone hybrid hydrogel to systematically investigate its potential for bone regeneration. The results showed that nano fish bone incorporation could not only enhance the mechanical performance of hybrid hydrogel but also modulate the immune microenvironment to further promote bone regeneration. This nano fish bone-based hybrid hydrogel would provide a promising option for developing advanced bone biomaterials with osteoimmunomodulatory activities.
Topics & Concepts
GelatinRegeneration (biology)Fish boneMaterials scienceBiomedical engineeringMethacrylateSelf-healing hydrogelsBone healingNano-NanotechnologyFish <Actinopterygii>ChemistryAnatomyCell biologyComposite materialBiologyPolymer chemistryMedicineBiochemistryPolymerPolymerizationFisheryBone Tissue Engineering MaterialsGraphene and Nanomaterials ApplicationsNanoplatforms for cancer theranostics