Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum
Xinyu Yu, Changhong Wang, Yuemeng Zhao, Jianxia Tang, Meng Zhu, Lucien Platon, Richard Culleton, Guoding Zhu, Didier Ménard, Qingfeng Zhang, Jun Cao
Abstract
mutations showed significant alterations in the tricarboxylic acid (TCA) cycle, glycolysis, and amino acids metabolism, pointing to altered energy and porphyrin metabolism with metabolic plasticity. The critical role of these pathways was further confirmed by altering metabolic flow or through chemical inhibition. Our findings uncover that the growth arrestment associated with ART-R is potentially attributed to the adaptative metabolic plasticity, indicating that the defined metabolic remodeling turns out to be the trigger for ART-R.
Topics & Concepts
ArtemisininPlasmodium falciparumBiologyMetabolomeGlycolysisCitric acid cycleMetabolic pathwayMalariaCell biologyMetabolismDihydroartemisininMetabolomicsBiochemistryBioinformaticsImmunologyMalaria Research and ControlTrypanosoma species research and implicationsMosquito-borne diseases and control