Thrombotic thrombocytopenia due to SARS-CoV-2 vaccination
Keith R. McCrae
Abstract
Vaccine-induced thrombotic thrombocytopenia (VITT) has been reported after vaccination with the AztraZeneca ChAdOx1 nCoV-19 and the Johnson and Johnson Ad26. COV2.S vaccines. This manuscript provides a brief overview of reported cases, clinical and laboratory features, and current understanding of the pathogenesis of VITT. The author also poses unananswered questions and identifies directions for future study.
Topics & Concepts
MedicineVaccinationSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakImmunologyIntensive care medicinePathogenesisVirologyInternal medicineDiseaseInfectious disease (medical specialty)OutbreakHeparin-Induced Thrombocytopenia and ThrombosisPlatelet Disorders and TreatmentsIntramuscular injections and effects