Straightforward Synthesis of Alkyl Fluorides via Visible-Light-Induced Hydromono- and Difluoroalkylations of Alkenes with α-Fluoro Carboxylic Acids
Chunfang Guo, Xuliang Han, Yu Feng, Zhaolong Liu, Yueyun Li, Hui Liu, Lizhi Zhang, Yunhui Dong, Xinjin Li
Abstract
We herein report the first visible-light-induced hydromono- and difluoroalkylations of alkenes with inexpensive and easily accessible α-fluoro carboxylic acids. This metal-free protocol exhibits mild conditions, high efficiency, and excellent functional-group tolerance, providing a straightforward approach to mono- and difluoroalkylated alkanes. Moreover, the fluorine effect on the hydrofluoroalkylation reaction is discussed in detail.
Topics & Concepts
AlkylFluorineVisible spectrumChemistryFunctional groupCarboxylic acidCombinatorial chemistryReaction conditionsMetalOrganic chemistryMaterials scienceCatalysisOptoelectronicsPolymerFluorine in Organic ChemistryRadical Photochemical Reactions