Diastereodivergent aminocatalyzed spirocyclization strategies using 4-alkylideneisoxazol-5-ones and methyl vinyl ketones
Amanda F. da Silva, Ives A. Leonarczyk, Marco A. B. Ferreira, Igor D. Jurberg
Abstract
Diasterodivergent aminocatalyzed approaches starting from 4-alkylideneisoxazol-5-ones and methyl vinyl ketones have been developed for the synthesis of racemic 6,10-<italic>cis</italic>-spiroisoxazol-5-ones and highly enantioenriched 6,10-<italic>trans</italic>-spiroisoxazol-5-ones.
Topics & Concepts
ChemistryMethyl vinyl ketoneOrganic chemistryCombinatorial chemistryMedicinal chemistryStereochemistryCatalysisAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions