Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts
SiddabasaveGowda B. Gowda, Divyavani Gowda, Vasundhara Kain, Hitoshi Chiba, Shu‐Ping Hui, Charles E. Chalfant, Vibhu Parcha, Pankaj Arora, Ganesh V. Halade
Abstract
Previous studies indicate that sphingosine-1-phosphate (S1P) has some role in cardiovascular disease. This study adds quantitative and integrative systems-based approaches that are necessary for discovery and bedside translation. Here, we quantitated sphinganine, sphingosine, sphingosine-1-phosphate (S1P) in mice and human cardiac pathobiology. Interorgan S1P quantity and respective systems-based receptor activation suggest cardiac repair after myocardial infarction. Thus, S1P serves as a therapeutic target for cardiac protection in clinical translation.
Topics & Concepts
Heart failureS1PR1SpleenSphingosineInflammationSphingosine-1-phosphate receptorSphingosine-1-phosphateMyocardial infarctionReceptorMedicineInternal medicineLipid signalingEndocrinologySphingolipidAgonistSphingosine kinasePharmacologyCardiologyBiologyCell biologyVascular endothelial growth factorVEGF receptorsVascular endothelial growth factor ASphingolipid Metabolism and SignalingEndoplasmic Reticulum Stress and DiseaseInflammasome and immune disorders