An AIE-active type I photosensitizer based on <i>N,N</i>′-diphenyl-dihydrophenazine for high-performance photodynamic therapy under hypoxia
Sifan Li, Xin Jin, Zhiyun Zhang, Jing Li, Jianli Hua
Abstract
An AIE-active type I photosensitizer DMPpy based on DHP was developed to efficiently generate superoxide anion radical (O 2 − ˙) for overcoming the hypoxic dilemma in solid tumors with NIR emission (∼700 nm), large Stokes shifts (∼270 nm) and mitochondrial targeting ability.
Topics & Concepts
PhotosensitizerPhotodynamic therapySuperoxidePhotochemistryChemistryAggregation-induced emissionBiochemistryFluorescenceOrganic chemistryOpticsPhysicsEnzymeNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies