Negative-pressure-assisted ventilation lowers driving pressure and mechanical power in an ARDS model
Elizabeth Rohrs, Thiago Bassi, Michelle Nicholas, Jessica Wittmann, Marlena Ornowska, K. Fernández, Matt Gani, Steven Reynolds
Abstract
Combining temporary transvenous diaphragm neurostimulation with volume-control ventilation on every breath, called negative-pressure-assisted ventilation, improved gas exchange and alveolar homogeneity in a preclinical model of moderate ARDS. Transpulmonary driving pressure, mechanical power, and mechanical work reductions were observed and resulted in lower lung injury scores and tissue cytokine concentrations in the every-breath-neurostimulation group compared with volume-control ventilation only. Negative-pressure-assisted ventilation is an exciting new potential tool to reduce ventilator-induced lung injury in patients with ARDS.