Metal-free tandem carbene N–H insertions and C–C bond cleavages
Pu Chen, Jiang Nan, Yan Hu, Yifan Kang, Bo Wang, Yangmin Ma, Michal Szostak
Abstract
Ar/C-C cleavage/aromatization reaction, and the synthetic utility of this new transformation is exemplified by the succinct syntheses of trisphaeridine and bicolorine alkaloids.
Topics & Concepts
AnnulationDiazoChemistryTandemAromatizationCleavage (geology)Bond cleavageCarbeneStereochemistryMetalCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisMaterials scienceFracture (geology)Composite materialCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloids