Copper-Catalyzed Radical 1,2-Carbotrifluoromethylselenolation of Alkenes under Ambient Conditions
Jiao Yu, Ning‐Yuan Yang, Jiangtao Cheng, Tian‐Ya Zhan, Cheng Luan, Yujing Liu, Qiang‐Shuai Gu, Zhong‐Liang Li, Guo‐Qiang Chen, Xin‐Yuan Liu
Abstract
We have described a copper-catalyzed radical 1,2-carbotrifluoromethylselenolation of alkenes using the readily available alkyl halides and (Me4N)SeCF3 salt. Critical to the success is the use of a proline-based N,N,P-ligand to enhance the reducing capability of copper for easy conversion of diverse alkyl halides to the corresponding radicals via a single-electron transfer process. The reaction features a broad substrate scope, including various mono-, di-, and trisubstituted alkenes with many functional groups.
Topics & Concepts
ChemistryHalideAlkylCopperCatalysisRadicalSubstrate (aquarium)Ligand (biochemistry)Combinatorial chemistrySalt (chemistry)Functional groupOrganic chemistryPhotochemistryReceptorBiochemistryPolymerOceanographyGeologyFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsRadical Photochemical Reactions