A Photocurable Elastic Polyester‐Based Janus Bio‐Adhesive for Press‐Induced In Situ Wound Closure
Junfeiyang Yin, Yü Liu, Rui Zhao, Ruijun Peng, Zihan Wang, Meng Long, Jie Xu, Hong Meng, Ling Wang, Wenhua Huang, Yaobin Wu
Abstract
Abstract Tissue bio‐adhesives are a promising solution for wound closure. However, most bio‐adhesives exhibit a significant decrease in adhesion strength in dynamic environments, making it challenging to provide adequate mechanical properties and personalized morphology that match native tissues. To address these limitations, this study presents an elastic polyester (POMCN) developed by blending poly (octamethylene maleate (acid anhydride) citrate) (POMC) precursor and acrylic acid N‐hydroxy succinimide (AA‐NHS) esters, followed by ultraviolet (UV) induced crosslinking. POMCN possesses in situ photopolymerization capability, enabling covalent crosslinking with amine groups to maintain long‐term and robust adhesion. To accommodate various wound types, both the mechanical and adhesive properties of POMCN can be tuned by adjusting the AA‐NHS content. Subsequently, a water‐soluble starch film is introduced to facilitate POMCN application, enhancing tissue adhesion and ensuring better conformity to wound morphology. The in vivo animal model experiments demonstrated that the POMCN patch significantly improved wound closure, promoted healing, and effectively prevented postsurgical adhesions. Collectively, the application of an elastic polyester patch with an in situ photopolymerization presents an efficient strategy route for dynamic wound healing, offering immense potential for improving clinical outcomes and restoring tissue integrity.