SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition
Issei Tomita, Shinji Kume, Sho Sugahara, Norihisa Osawa, Kosuke Yamahara, Mako Yasuda‒Yamahara, Naoko Takeda, Masami Chin‒Kanasaki, Tatsuroh Kaneko, Eric Mayoux, Michael Mark, Motoko Yanagita, Hisakazu Ogita, Shin‐ichi Araki, Hiroshi Maegawa
Topics & Concepts
mTORC1EmpagliflozinKetogenesisKetone bodiesEndocrinologyInternal medicineLipolysisCatabolismKidneyMonoacylglycerol lipaseChemistryType 2 diabetesMedicinePharmacologyDiabetes mellitusAdipose tissuePI3K/AKT/mTOR pathwayMetabolismApoptosisBiochemistryReceptorEndocannabinoid systemPancreatic function and diabetesDiabetes Treatment and ManagementDiet, Metabolism, and Disease