Pseudomonas aeruginosa Resists Phage Infection via Eavesdropping on Indole Signaling
Guanhua Xuan, Qin Dou, Jiuna Kong, Hong Lin, Jingxue Wang
Abstract
Our finding is significant with respect to the study of the interactions between phage and host. Although the important roles of indole in bacterial physiology have been revealed, no direct examples of indole participating in phage-host interactions were reported. This study reports that indole could modulate the phage resistance of indole-nonproducing Pseudomonas aeruginosa PAO1 through inhibition of phage adsorption mechanism. Our finding will be significant for guiding phage therapy and fill some gaps in the field of phage-host interactions.
Topics & Concepts
Pseudomonas aeruginosaEavesdroppingIndole testMicrobiologyBiologyPseudomonadalesComputational biologyGeneticsBacteriaComputer scienceComputer securityBiochemistryBacteriophages and microbial interactionsBacterial Genetics and BiotechnologyCRISPR and Genetic Engineering