Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Mihoko Yoshino, Jun Yoshino, Brandon D. Kayser, Gary J. Patti, Michael P. Franczyk, Kathryn F. Mills, Miriam Sindelar, Terri Pietka, Bruce W. Patterson, Shin‐ichiro Imai, Samuel Klein
Abstract
Anti-aging supplement effects in humans Synthesis of nicotinamide adenine dinucleotide (NAD + ) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity. Studies in animals indicate that replenishment of cellular NAD + can have beneficial effects on aging and age-related diseases, but the situation in humans is less clear. Yoshino et al. report the effects of supplementation with the NAD + precursor nicotinamide mononucleotide in overweight or obese postmenopausal women with prediabetes (see the Perspective by Hepler and Bass). The treatment improved insulin sensitivity in muscle, although a change in NAD + content was not detected. The treatment also increased the expression of platelet-derived growth factor b. The results support potential therapeutic action of NAD + supplementation in humans, but how various NAD+ precursors are processed in specific tissues remains to be fully explored. Science , abe9985, this issue p. 1224 ; see also abj0764, p. 1147