Concurrent High PD-L1 Expression and CD8+ Immune Cell Infiltration Predict PD-1 Blockade Efficacy in Advanced EGFR-Mutant NSCLC Patients
Yukiko Shimoda, Ryota Shibaki, Tatsuya Yoshida, Shuji Murakami, Masayuki Shirasawa, Masahiro Torasawa, Yuji Matsumoto, Ken Masuda, Yuki Shinno, Yusuke Okuma, Yasushi Goto, Hidehito Horinouchi, Noboru Yamamoto, Yuichiro Ohe, Noriko Motoi
Topics & Concepts
MedicineBlockadePD-L1Lung cancerImmune systemCytotoxic T cellCD8MutantCancer researchInfiltration (HVAC)Immune checkpointProgrammed cell death 1OncologyImmunotherapyInternal medicineImmunologyReceptorGeneBiochemistryIn vitroPhysicsChemistryThermodynamicsCancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsLung Cancer Research Studies