Neuropharmacological Effects of Quercetin: A Literature-Based Review
Md. Shahazul Islam, Cristina Quispe, Rajib Hossain, Muhammad Torequl Islam, Ahmed Al‐Harrasi, Ahmed Al‐Rawahi, Miquel Martorell, Assem Mamurova, Ainur Seilkhan, Nazgul Altybaeva, Bagila Abdullayeva, Anca Oana Docea, Daniela Călina, Javad Sharifi‐Rad
Abstract
animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer's disease, Amyloid β peptide, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.