A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention
Sheng Wei, Xiwen Geng, Zifa Li, Kaiyong Xu, Minghui Hu, Hongyun Wu, Wei Shi, Mingqi Qiao
Abstract
receptor 4α subunit, all of which were reversed to physiological levels by fluoxetine. Overall, we established a reliable and standardized rat model of premenstrual depression, which may facilitate the elucidation of PMS/PMDD pathogenesis and development of related therapies.
Topics & Concepts
Depression (economics)Intervention (counseling)HormonePsychologyBehavioural despair testDrugRat modelInternal medicinePsychiatryMedicineAntidepressantAnxietyMacroeconomicsEconomicsMenstrual Health and DisordersBiochemical effects in animalsStress Responses and Cortisol