Antimalarial activity of curcumin and kaempferol using structure-based drug design method
Maulana Yusuf Alkandahri, Recky Patala, Afiat Berbudi, Anas Subarnas
Abstract
Malaria is a major global health problem caused by plasmodium parasites. The alarming spread of drug resistance and its limited availability underscores the importance of discovering new antimalarial compounds. This study aims to examine the interaction of curcumin and kaempferol on the triose-phosphate isomerase receptor of P. falciparum strain through an in-silico trial using a structure-based drug design method. Molecular docking was performed using crystalline protein triose-phosphate isomer
Topics & Concepts
CurcuminKaempferolDrugTraditional medicinePharmacologyChemistryComputer scienceMedicineQuercetinOrganic chemistryAntioxidantComputational Drug Discovery MethodsSynthesis and biological activityDiverse Scientific Research Studies