Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice
Gustaf Christoffersson, Sowbarnika S. Ratliff, Matthias G. von Herrath
Abstract
T cells. Islet-resident macrophages expressed adrenoceptors and were responsive to catecholamines. Islet macrophages may therefore constitute a pivotal neuroimmune signaling relay and could be a target for future interventions in T1D.
Topics & Concepts
Immune systemDiabetes mellitusPancreasDiseaseMedicineType 2 diabetesSignal transductionEndocrinologyInterference (communication)Internal medicineNeuroscienceBiologyImmunologyCell biologyComputer scienceComputer networkChannel (broadcasting)Vagus Nerve Stimulation ResearchHeart Rate Variability and Autonomic ControlDietary Effects on Health