Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral <i>Sinularia nanolobata</i>
Zi-Rong Zeng, Wang-Sheng Li, Bastien Nay, Pei Hu, Haiyan Zhang, Hong Wang, Xu‐Wen Li, Yue‐Wei Guo
Abstract
A novel diterpenoid, sinunanolobatone A (1), featuring an unprecedented bicyclo[13.1.0]pentadecane carbon framework, along with two new casbane diterpenoids (2 and 3), and five known related ones (4–8) were isolated from the Sanya soft coral Sinularia nanolobata. The structures of the new compounds were established by detailed spectroscopic analysis, X-ray diffraction analysis, chemical reactions, or a quantum chemical computation method. A plausible biosynthetic pathway of 1 was proposed. In bioassay, the novel compound 1 showed significant inhibitory activity against lipopolysaccharide (LPS) induced inflammation in BV-2 microglial cells.
Topics & Concepts
PentadecaneChemistryCoralTerpenoidBicyclic moleculeQuantum chemicalStereochemistryOrganic chemistryMoleculeBiologyEcologyMarine Sponges and Natural ProductsNatural product bioactivities and synthesisPhytochemical Studies and Bioactivities