Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring
Pierre Didier, Nicolas Lobato‐Dauzier, Nicolas Clément, Anthony J. Genot, Yui Sasaki, Éric Leclerc, Tsukuru Minamiki, Yasuyuki Sakai, Teruo Fujii, Tsuyoshi Minami
Abstract
Abstract Organic field‐effect transistors (OFETs) can be potentially employed to monitor cell activities for healthcare and medical treatment because of their attractive properties such as ease of use, flexibility, and low‐cost manufacturing processes. Although current OFET‐based sensors are suitable for point‐of‐care testing, the establishment of real‐time monitoring methods is in high demand for continuous monitoring of health conditions and/or biological cell activities. In this regard, we herein propose a microfluidic platform integrated with an extended‐gate‐type OFET for real‐time glucose monitoring. The mechanism of glucose detection depends on the artificial receptor phenylboronic acid and its boronate esterification. After optimization of the microfluidics for the OFET‐based sensor, the sensor was used to monitor glucose consumption and release in a model of pseudo‐liver cells. Random increases or decreases in the glucose concentration were reproducibly monitored.