Increased suicidal erythrocyte death in patients with hepatitis B-related acute-on-chronic liver failure
Cheng Mei, Fang Peng, Wen-Yu Yin, Wei Xu, Run Yao, Bijuan Li, Rongrong Zhou, Xuegong Fan, Ning Li
Abstract
Acute chronic liver failure (ACLF) is a critical syndrome characterized by multiple organ failures and high short-term mortality. A common complication of HB-ACLF is anemia, however, the mechanism of anemia in HB-ACLF remains to be elucidated. We confirm that the accelerated eryptosis is involved in the pathophysiology of anemia associated with HB-ACLF, which progressively aggravates the clinical outcome. Our study illustrates the mechanism regarding the anemia pathogenesis of HB-ACLF, which may be utilized further toward therapeutic ends.
Topics & Concepts
MedicineAnemiaPathogenesisPathophysiologyChronic hepatitisMechanism (biology)Liver failureComplicationImmunologyInternal medicineEpistemologyPhilosophyVirusErythrocyte Function and PathophysiologyDiabetes and associated disordersHemoglobinopathies and Related Disorders