Fibrin Sealants: Challenges and Solutions
Matthias Beudert, Marcus Gutmann, Tessa Lühmann, Lorenz Meinel
Abstract
Intraoperative bleeding and postoperative bleeding are major surgical complications. Tissue sealants, hemostats, and adhesives provide the armamentarium for establishing hemostatic balance, including the tissue sealant fibrin. Fibrin sealants combine advantages including instantaneous effect, biocompatibility, and biodegradability. However, several challenges remain. This review summarizes current fibrin product generations and highlights new trends and potential strategies for future improvement.
Topics & Concepts
SealantFibrinFibrin Tissue AdhesiveBiocompatibilityHemostasisBiomedical engineeringHemostatSurgeryMedicineMaterials scienceComposite materialImmunologyMetallurgyHemostasis and retained surgical itemsSurgical Sutures and AdhesivesBlood transfusion and management