Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection
Rohini Dwivedi, Priyanka Samanta, Poonam Sharma, Fuming Zhang, Sushil K. Mishra, Pavel Kucheryavy, Seon Beom Kim, AyoOluwa O. Aderibigbe, Robert J. Linhardt, Ritesh Tandon, Robert J. Doerksen, Vitor H. Pomin
Abstract
values (in the nanomolar range) 6, 25, and 6 times more efficient than heparin, respectively. Data from computational simulations suggest an influence of the sulfation patterns of the Fuc units on hydrogen bonding with GlcA and that conformational change of some of the oligosaccharide structures occurs upon S-protein RBD binding. Compared with heparin, negligible anticoagulant action was observed for IbSF. Our results suggest that IbSF may represent a promising molecule for future investigations against SARS-CoV-2.
Topics & Concepts
SulfationSurface plasmon resonanceDissociation constantChemistryHeparinChondroitin sulfateGlycanStereochemistryHeparan sulfateIC50BiochemistryBiophysicsGlycosaminoglycanReceptorIn vitroBiologyGlycoproteinMaterials scienceNanotechnologyNanoparticleEchinoderm biology and ecologyTravel-related health issuesInfluenza Virus Research Studies