Role of Staphylococcus aureus Formate Metabolism during Prosthetic Joint Infection
Blake P. Bertrand, Cortney E. Heim, Sean West, Sujata S. Chaudhari, Hesham Ali, Vinai C. Thomas, Tammy Kielian
Abstract
Biofilms are bacterial communities characterized by antibiotic tolerance. Staphylococcus aureus is a leading cause of biofilm infections on medical devices, including prosthetic joints, which represent a significant health care burden. The major leukocyte infiltrate associated with S. aureus prosthetic joint infection (PJI) is granulocytic myeloid-derived suppressor cells (G-MDSCs), which produce IL-10 to promote biofilm persistence by inhibiting monocyte and macrophage proinflammatory activity.
Topics & Concepts
Staphylococcus aureusBiofilmMicrobiologyBiologyProinflammatory cytokineFormateStaphylococcal infectionsMultidrug tolerancePopulationBacteriaImmunologyInflammationBiochemistryMedicineGeneticsCatalysisEnvironmental healthBacterial biofilms and quorum sensingOrthopedic Infections and TreatmentsAntimicrobial Peptides and Activities