Ruthenium(<scp>ii</scp>)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers
Gregory F. Grawe, Katia M. Oliveira, Celisnólia M. Leite, Tamires D. de Oliveira, João Honorato, Antônio G. Ferreira, E.E. Castellano, Márcia R. Cominetti, Rodrigo S. Corrêa, Alzir A. Batista
Abstract
minor grooves. These complexes also interact with human serum albumin (HSA) and have affinity for site I by hydrophobic forces. Therefore, this new class of ruthenium complexes can act as cytotoxic agents, mainly for lung cancer treatment.
Topics & Concepts
RutheniumThioureaCytotoxicityA549 cellChemistryCisplatinCytotoxic T cellLigand (biochemistry)ApoptosisStereochemistryIn vitroReceptorBiochemistryBiologyChemotherapyOrganic chemistryGeneticsCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsCrystal structures of chemical compounds