Serological Profiling of Group A <i>Streptococcus</i> Infections in Acute Rheumatic Fever
Natalie Lorenz, Timothy K.C. Ho, Reuben McGregor, Mark R. Davies, Deborah A. Williamson, Jason Gurney, Pierre R. Smeesters, Michael G. Baker, Nicole J. Moreland
Abstract
Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.
Topics & Concepts
SequelaMedicineSerologyRheumatic feverImmunologyPathogenesisStreptococcusAcute rheumatic feverGroup AVirologyAntibodyInternal medicineBiologyBacteriaGeneticsPsychiatryStreptococcal Infections and TreatmentsAntimicrobial Resistance in StaphylococcusToxin Mechanisms and Immunotoxins