PIPAC versus HIPEC: cisplatin spatial distribution and diffusion in a swine model
Axel Davigo, Guillaume Passot, Olivia Vassal, Muriel Bost, C. Tavernier, Évelyne Decullier, Naoual Bakrin, Mohammad Alyami, Jeanne‐Marie Bonnet‐Garin, Vanessa Louzier, Christian Paquet, Bernard Allaouchiche, Olivier Gléhen, Vahan Képénékian
Abstract
With doses used in clinical practice, HIPEC guaranteed a higher cisplatin peritoneal uptake than PIPAC in this swine model. Spatial drug distribution was heterogeneous with both technics, with hotspots closed to the drug delivery sites. Nevertheless, considering the dose ratio, IP drug uptake yield was better with PIPAC.
Topics & Concepts
CisplatinHyperthermic intraperitoneal chemotherapyPharmacokineticsMedicineChemotherapyDistribution (mathematics)Peritoneal cavityAnesthesiaSurgeryPharmacologyInternal medicineCytoreductive surgeryCancerMathematical analysisMathematicsOvarian cancerIntraperitoneal and Appendiceal MalignanciesAppendicitis Diagnosis and ManagementHernia repair and management