Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection
Giovanni Luchetti, Justin L. Roncaioli, Roberto A. Chavez, Alexander F. Schubert, Eric M. Kofoed, Rohit Reja, Tommy K. Cheung, Yuxin Liang, Joshua D. Webster, Isabelle Lehoux, Elizabeth Skippington, Janina Reeder, Benjamin Haley, Man Tan, Christopher M. Rose, Kim Newton, Nobuhiko Kayagaki, Russell E. Vance, Vishva M. Dixit
Topics & Concepts
BiologyPyroptosisUbiquitin ligaseMicrobiologyShigellaUbiquitinDegradation (telecommunications)DNA ligaseComputational biologyBacteriaBiochemistryGeneticsSalmonellaEnzymeApoptosisComputer scienceGeneProgrammed cell deathTelecommunicationsInflammasome and immune disordersAutoimmune and Inflammatory Disorders ResearchGout, Hyperuricemia, Uric Acid