Biofabricated silver nanoparticles exhibit broad-spectrum antibiofilm and antiquorum sensing activity against Gram-negative bacteria
Faizan Abul Qais, Iqbal Ahmad, Mohammad Altaf, Salim Manoharadas, Basel F. Alrayes, Mohammed Saeed Ali Abuhasil, Yaser A. Almaroai
Abstract
PAO1 was reduced by 87.39, 81.54, and 71.34%, respectively. Biofilms on glass surfaces were remarkably reduced, with less aggregation of bacterial cells and the reduced formation of extra polymeric substances. The findings clearly show the efficacy of AgNPs-MK against the development of biofilms and the QS mediated virulent traits of Gram negative bacterial pathogens. AgNPs-MK may be further exploited for the development of alternative antimicrobial agents after careful scrutiny in animal models for the management of bacterial infections, especially for topical applications.
Topics & Concepts
Broad spectrumBacteriaChemistryNanotechnologySilver nanoparticleGram-negative bacteriaBiofilmNanoparticleMaterials scienceCombinatorial chemistryBiochemistryBiologyEscherichia coliGeneticsGeneBacterial biofilms and quorum sensingNanoparticles: synthesis and applicationsAdvanced Nanomaterials in Catalysis