Light-induced efficient and residue-selective bioconjugation of native proteins <i>via</i> indazolone formation
An‐Di Guo, Ke-Huan Wu, Xiaohua Chen
Abstract
and in living systems. This straightforward protocol demonstrates the generality and accessibility for direct and rapid functionalization of diverse native proteins, which suggests a new avenue of great importance to bioconjugation, medicinal chemistry and chemical biology.
Topics & Concepts
BioconjugationResidue (chemistry)ChemistryCombinatorial chemistryBiochemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisPeptidase Inhibition and Analysis