Association of Initial Side of Brain Atrophy With Clinical Features and Disease Progression in Patients With <i>GRN</i> Frontotemporal Dementia
Sergi Borrego‐Écija, Jordi Juncà‐Parella, Marijne Vandebergh, Agnès Pérez‐Millan, Mircea Balasa, Albert Lladó, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry‐Bolder, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Florence Pasquier, Simon Ducharme, Christopher Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermín Moreno, Barbara Borroni, Rosa Rademakers, Jonathan D. Rohrer, Raquel Sánchez‐Valle, for the Genetic Frontotemporal Initiative (GENFI)
Abstract
BACKGROUND AND OBJECTIVES: depends on the initial side of the atrophy. We also investigated the potential use of brain asymmetry as a biomarker of the disease. METHODS: and compared their clinical features and disease progression. We generated generalized additive models to study how the asymmetry index evolves in carriers and noncarriers and compare its models with others created with volumetric values and plasma neurofilament light chain. RESULTS: carriers 10.4 years before the onset of the symptoms (standard difference 0.85, CI 0.01-1.68). DISCUSSION: carriers.