Systemic and brain delivery of leptin via intranasal coadministration with cell-penetrating peptides and its therapeutic potential for obesity
El‐Sayed Khafagy, Noriyasu Kamei, Yui Fujiwara, Haruka Okumura, Teruyo Yuasa, Masahiro Kato, Kenji Arime, Anna Nonomura, Hideyuki Ogino, Serena Hirano, Sayaka Sugano, Mariko Takeda‐Morishita
Topics & Concepts
LeptinNasal administrationHypothalamusAppetiteEndocrinologyMedicineInternal medicineCentral nervous systemLeptin receptorBlood–brain barrierHormoneCell-penetrating peptidePharmacologyObesityChemistryCellBiochemistryRNA Interference and Gene DeliveryRegulation of Appetite and ObesityLipid Membrane Structure and Behavior