SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
Ian Barr, Cleve Rynehart, Paul G. Whitney, Julian Druce
Abstract
The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen's eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.
Topics & Concepts
EmbryonatedVirologyBiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Cell cultureMicrobiologyBetacoronavirusRespiratory systemVirusCoronavirus disease 2019 (COVID-19)MedicineGeneticsDiseaseAnatomyPathologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchInfluenza Virus Research StudiesRespiratory viral infections research