Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids
Yu Zhao, Ruoxin Li, Pingchuan Liu, J J Wang, Yanru Cui, Yufei Ma, Zhongye Cao, Meng Cui, Sijin Luozhong, Erica Wagner, Amy D. Laflin, Yaopeng Ding, Yuping Hu, Zhen Tian, Chenjue Tang, Simian Cai, Hamilton Young, Di Liu, Wenchao Gu, Sean T. Bailey, Shaoyi Jiang
Topics & Concepts
ChemistryMessenger RNAEndosomeBiochemistryProtonationLiposomeCytotoxicityBiophysicsImmunogenicityNanoparticleInflammationBiocompatibilityCell biologyPhosphatidylcholineApoptosisLipid bilayerCytotoxic T cellTertiary amineCancer cellGene knockdownAmine gas treatingLipid ALipid vesicleEndocytosisDrug carrierCellCytokineNanocarriersImmunogenCancer immunotherapyAntigenRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics